Master General Surgery
for SMLE
Access 50+ high-yield questions tailored for the 2026 syllabus. Includes AI-powered explanations and performance tracking.
Core Concepts
- **Scope:** Diagnosis & management of diseases involving the GI tract (esophagus to rectum), endocrine glands (thyroid, parathyroid, adrenal, pancreas), breast, soft tissues, vascular system, and acute surgical conditions (trauma, critical care).
- **Key Principles:**
- **Acute vs. Elective:** Differentiate urgent surgical emergencies from planned procedures.
- **Sterile Technique:** Fundamental for preventing surgical site infections.
- **Pre-operative Assessment:** Optimize patient health to minimize risks (cardiac, pulmonary, renal, nutrition, NPO, DVT/antibiotic prophylaxis).
- **Post-operative Care:** Pain management, fluid balance, early mobilization, monitoring for complications (bleeding, infection, DVT/PE, ileus, anastomotic leak).
- **Shock & Resuscitation:** Recognize and manage hypovolemic, septic, cardiogenic, obstructive shock (ATLS principles for trauma).
Clinical Presentation
- **Acute Abdomen:** Sudden severe abdominal pain.
- **Appendicitis:** Periumbilical pain migrating to RIF, anorexia, N/V, fever, McBurney's tenderness.
- **Acute Cholecystitis:** RUQ pain radiating to R shoulder/back, fever, N/V, positive Murphy's sign.
- **Diverticulitis:** LLQ pain, fever, altered bowel habits (often elderly).
- **Small Bowel Obstruction (SBO):** Colicky pain, vomiting, distension, absolute constipation, tinkling bowel sounds.
- **Perforated Viscus (e.g., Peptic Ulcer):** Sudden, severe, generalized abdominal pain, guarding, "board-like" rigidity.
- **Acute Pancreatitis:** Severe epigastric pain radiating to back, N/V.
- **Ruptured AAA:** Sudden severe back/abdominal pain, hypotension, pulsatile abdominal mass.
- **Gastrointestinal Bleeding:** Hematemesis/melena (UGI), hematochezia (LGI).
- **Hernias:** Palpable bulge; pain, irreducibility, or strangulation signs (erythema, systemic toxicity) are critical.
- **Breast Lumps:** Palpable mass, skin changes (peau d'orange), nipple discharge/retraction.
- **Thyroid Pathology:** Neck lump/swelling (goiter), dysphagia, dyspnea, hoarseness, +/- hypo/hyperthyroid symptoms.
- **Trauma:** Injuries following blunt/penetrating force; focus on ABCDE assessment.
- **Surgical Infections:** Localized pain, swelling, redness, warmth, fever (e.g., abscesses, cellulitis, necrotizing fasciitis).
- **Vascular:**
- **Peripheral Arterial Disease (PAD):** Intermittent claudication, rest pain, trophic changes, non-healing ulcers.
- **Deep Vein Thrombosis (DVT):** Leg pain, swelling, tenderness, warmth, erythema.
Diagnosis (Gold Standard)
- **History & Physical Examination:** Always the first and most crucial step.
- **Laboratory Tests:** CBC (leukocytosis, anemia), U&E, LFT, Amylase/Lipase, Coagulation profile, G&S, ABG.
- **Imaging:**
- **Plain Radiographs (CXR/AXR):** CXR: free air under diaphragm (perforation). AXR: dilated bowel loops, air-fluid levels (SBO).
- **Ultrasound (US):** Highly useful for gallstones/cholecystitis, appendicitis (peds/pregnant), AAA, DVT, breast lumps, thyroid nodules.
- **Computed Tomography (CT) Scan:** **Often gold standard for acute abdomen** (appendicitis, diverticulitis, perforation, AAA, trauma assessment, staging malignancy). CT angiography for vascular disease.
- **Endoscopy (EGD/Colonoscopy):** Gold standard for diagnosing and often treating GI bleeding, strictures, masses.
- **Biopsy (Histopathology):** **Definitive for malignancy** (breast, thyroid, GI masses).
- **Angiography:** Gold standard for vascular lesions (PAD, acute ischemia).
Management (First Line)
- **Resuscitation & Stabilization:**
- **ABCDE Assessment:** Prioritize airway, breathing, circulation.
- **IV Fluids:** Crystalloids (e.g., Normal Saline, Ringer's Lactate) for hypovolemia/shock.
- **Oxygen:** Supplemental O2 for hypoxia.
- **Analgesia:** Early pain control (e.g., opioids).
- **NPO & Nasogastric Tube (NGT):** For bowel obstruction, pancreatitis, pre-op.
- **Antibiotics:** Empiric broad-spectrum for suspected infection (e.g., intra-abdominal sepsis, diverticulitis, cholecystitis) or prophylaxis.
- **Specific Surgical Interventions:**
- **Acute Appendicitis/Cholecystitis:** Laparoscopic appendectomy/cholecystectomy.
- **Perforated Viscus:** Emergency exploratory laparotomy with primary repair or resection.
- **Small Bowel Obstruction (SBO):** Initial conservative management (NPO, NGT, IV fluids); surgical lysis of adhesions or resection for strangulation/failure of conservative Rx.
- **Hernia:** Elective repair (herniorrhaphy/hernioplasty); emergency repair for incarcerated/strangulated hernias.
- **GI Bleeding:** Endoscopic intervention (clipping, coagulation) often first line; surgical exploration for refractory bleeding.
- **Breast/Thyroid Cancer:** Surgical resection (mastectomy/thyroidectomy) + adjuvant therapy.
- **Trauma:** Damage control surgery for severe trauma, specific repairs based on injury.
- **Abscess:** Incision and drainage (I&D).
- **PAD:** Revascularization (angioplasty/stenting, bypass surgery) for critical limb ischemia.
- **DVT:** Anticoagulation (heparin followed by warfarin/DOACs).
Exam Red Flags
- **Peritonitis (Generalized Rigidity, Rebound Tenderness):** Suggests diffuse intra-abdominal inflammation/perforation, requires urgent surgical exploration.
- **Hemodynamic Instability/Shock:** Hypotension, tachycardia, altered mental status, indicates severe pathology (e.g., hemorrhage, sepsis) requiring immediate resuscitation and likely surgery.
- **Strangulated Hernia:** Painful, irreducible hernia with skin changes and systemic toxicity (fever, leukocytosis). **Surgical emergency** due to bowel ischemia.
- **Necrotizing Soft Tissue Infection (e.g., Necrotizing Fasciitis):** Severe pain out of proportion to exam, rapidly spreading erythema, crepitus, systemic toxicity. Requires **urgent radical debridement**.
- **Acute Limb Ischemia:** Sudden onset of "6 Ps": Pain, Pallor, Pulselessness, Paresthesia, Paralysis, Poikilothermia. **Surgical emergency** to prevent limb loss.
- **Ruptured Abdominal Aortic Aneurysm (AAA):** Sudden severe abdominal/back pain, pulsatile mass, hypotension. **Life-threatening emergency**, requires immediate transport to OR.
- **Septic Shock unresponsive to initial resuscitation:** Indicates ongoing source of infection that needs surgical control (drainage, debridement, resection).
Sample Practice Questions
A 45-year-old female presents for evaluation of a newly discovered, painless lump in her left breast. On clinical examination, the lump is 2 cm, firm, irregular, and fixed to the underlying tissue. There is no nipple discharge or axillary lymphadenopathy. She has no family history of breast cancer. What is the most appropriate next diagnostic step?
A 68-year-old male with a known history of a reducible right inguinal hernia presents to the emergency department with acute onset of severe pain in his right groin, associated with nausea and vomiting. On examination, there is a tender, firm, non-reducible mass in the right inguinal region. The overlying skin is erythematous and warm. He is tachycardic (HR 110 bpm) and afebrile.
A 25-year-old male presents to the emergency department with a 12-hour history of dull periumbilical pain that has now migrated and localized to the right lower quadrant. He reports anorexia and a single episode of nausea. On examination, his temperature is 38.5ยฐC, heart rate 98 bpm, and he exhibits guarding and rebound tenderness in the right iliac fossa. Laboratory tests show a white blood cell count of 15,000 cells/ยตL with neutrophilia. What is the most appropriate next step in the management of this patient?
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